CD23, une molécule plurifonctionnelle

Soluble CD23 in allergic diseases.

CD23, a differentiation marker of B cells is identified with the low-affinity receptor for IgE--FcepsilonRII. The CD23 molecule is continuously cleaved by autoproteolysis into soluble fragments called sCD23, considered as a multifunctional cytokine. sCD23 is supposed to play an important role in IgE synthesis. IgE is a hallmark of atopy and its overproduction is a characteristic feature of alle...

Importance of CD23 for collagen-induced arthritis: delayed onset and reduced severity in CD23-deficient mice.

Increased expression of the low affinity receptor for IgE, FcepsilonRII/CD23 has been observed in rheumatoid arthritis. In view of this, we have investigated the expression and influence of CD23 in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. CD23+ cells were analyzed in lymph nodes of DBA/1 mice immunized with bovine collagen type II (BCII) in CFA or with CFA onl...

Humoral response suppression observed with CD23 transgenics.

CD23, also known as the low affinity IgE receptor (FcepsilonRII), has been hypothesized to have a role in IgE regulation. A new CD23 transgenic mouse was generated using the MHC class I promoter and IgH enhancer to further test the hypothesis that CD23 plays a role in the down-regulation of IgE. Study of three founder lines by FACS showed overexpression to varying extents on both B and T lympho...

Une masse palpébrale révélant une fistule carotidocaverneuse

Abstract Les auteurs rapportent une observation particulière, chez un homme de 48 ans ayant dans ces antécédents un traumatisme crânio-faciale grave il y'a dix ans, qui présente depuis huit mois une masse palpébrale droite, avec une discrète exophtalmie et hémorragie sous conjonctivale, l'angio IRM a permis de confirmer le diagnostique d'une fistule carotidocaverneuse à haut débit, qui est resp...

Sur une souche de BRUCELLA d'origine humaine